In the Albumin Italian Outcome Sepsis (ALBIOS) trial, which is a multi-centric trial done on 1818 patients, it was found that PTX3 levels are elevated in severe sepsis and correlate significantly with prevalent and incident organ failures [27]. Similarly, in a prospective study done by Uusitalo-Seppälä et al., it was found that measuring PTX3 level at admission highly predicts severe sepsis and case fatality [28]. The gene discussed is PTX3; the disease is Sepsis.