An uncommon monogenic migraine with aura (MA) subtype known as hemiplegic migraine is caused by mutations in the calcium voltage-gated channel subunit alpha 1A (CACNA1A), ATPase Na+/K+ transporting subunit alpha 2 (ATP1A2), and sodium voltage-gated channel alpha subunit 1 (SCN1A) genes, all of which encode for ion channel and transport proteins [9]. The gene discussed is SCN1A; the disease is familial or sporadic hemiplegic migraine.