EMPA: empagliflozin; BMI: body mass index; T2DM: type 2 diabetes; Nrf2: nuclear factor erythroid 2-related factor 2; NAFLD: nonalcoholic fatty liver disease; RCT: randomized controlled trial; NMR: nuclear magnetic resonance; VAT: visceral adipose tissue; FG: fasting glucose; qd: quater die sumendus (four times a day). Here, NFE2L2 is linked to type 2 diabetes mellitus.