The present study investigated pyroptosis-related lncRNAs in COAD patients and constructed a risk model that included 9 lncRNAs (LINC01857, LINC00205, NUP153-AS1, LINC00944, ZKSCAN2-DT, DGUOK-AS1, LENG8-AS1, CAPN10-DT, and TNFRSF10A-AS1). Here, TNFRSF10A is linked to colon adenocarcinoma.