Five studies objectively measured cerebrospinal fluid (CSF) levels of the neuropeptide hypocretin‐1 (orexin)37, 41, 42, 43, 89 and two examined the potential underlying neuropathology of EDS, by obtaining neuronal counts within the nucleus basalis of Meynert (nBM), or measuring neocortical hypocretin.40, 41. Here, HCRT is linked to Ehlers-Danlos syndrome.