For instance, exosomal TGF‐β, miR‐10b, miR‐1247‐3p, and miR‐125b secreted by bladder, colorectal, liver, and breast cancer tumor cells, respectively, mediate the activation of CAFs [65, 66, 67, 68], which, in turn, promote tumor cells aggressiveness through the induction of proliferation, EMT, stemness, chemoresistance and/or tumorigenicity, among others [66, 67]. The gene discussed is TGFB1; the disease is neoplasm.