CXCL8 and chronic rhinosinusitis with nasal polyps: In China, we previously demonstrated that adult CRSwNP patients with enhanced tissue neutrophilia show poor respond to oral corticosteroids [3], and Liao et al. found increased IL-8 expression and more patients with difficult-to-treat CRSwNP in clusters with severe or moderate neutrophilic inflammation by performing a cluster analysis based on clinical variables and pathological features [6].