We previously showed IL-1β was upregulated in neutrophilic CRSwNP following NLRP3 inflammasome activation, which may contributes to NP neutrophilic inflammation [10], and an association between IL1A polymorphism and chronic rhinosinusitis has been demonstrated by other groups as well [11], but the possible role of IL-1α in the pathogenesis of CRSwNP remains unclear. The gene discussed is NLRP3; the disease is chronic rhinosinusitis with nasal polyps.