The most conserved core component of MACOM, WTAP, was discovered due to its relationship with Wilms’ tumor 1 (WT1) and was named as Wilms’ tumor 1-associated protein.31 WTAP has recently been shown to be upregulated in many tumors, such as acute myeloid leukemia.32,33 Our cryo-EM structures, especially the high-resolution structure of the MACOM core, provide a basis for the development of inhibitors or drugs targeting m6A modification to achieve potential therapeutic efficacy for human diseases such as cancers.24 This evidence concerns the gene WT1 and acute myeloid leukemia.