WT1 and cancer: The most conserved core component of MACOM, WTAP, was discovered due to its relationship with Wilms’ tumor 1 (WT1) and was named as Wilms’ tumor 1-associated protein.31 WTAP has recently been shown to be upregulated in many tumors, such as acute myeloid leukemia.32,33 Our cryo-EM structures, especially the high-resolution structure of the MACOM core, provide a basis for the development of inhibitors or drugs targeting m6A modification to achieve potential therapeutic efficacy for human diseases such as cancers.24