AKT1 and neoplasm: Studies had shown that Urolithin A could inhibit the PI3K/AKT/mTOR signaling pathway, thereby effectively reprogramming the fibroinflammatory tumor stroma, by reducing the immunosuppressive tumor-associated macrophages (TAMs) and increasing the recruitment of T cells in the TME of PDAC to achieve the effect of promoting the anti-tumor immune microenvironment30.