TOP2A and familial pancreatic carcinoma: The data suggested that 11 highly expressed genes, namely ASPM, CCNB1, CDK1, CENPK,, DDX60, MELK, MX1, OAS1, OAS3, PTTG1 and TOP2A were thought to be remarkably associated with shorter overall survival in pancreatic cancer patients (Fig. 4), and these genes significantly higher in tumor tissues than in normal tissues (Fig. 5A–K).