CGAS and neoplasm: The cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS)-stimulator of interferon gene (STING) signaling is an evolutionarily conserved DNA-sensing mechanism in human body and plays critical roles in regulating the crosstalk between tumor cells and ambient immune cells, which emerges as a promising target for improving the effectiveness of immunotherapy against solid tumors13,14.