Specifically, the maturity ratio of tumor-infiltrating DCs reached around 33% compared to the BSA-Man-Ft@Lap (17%) and BSA-Man@Mn2+-Ft groups (26%), suggesting the potent DC stimulating effect of the BSA-Man@Mn2+-Ft@Lap nanoassembly through cooperative tumor-derived dsDNA release and DC-targeted cGAS-STING stimulation. This evidence concerns the gene STING1 and neoplasm.