CGAS and neoplasm: During a typical treatment process, dsDNA derived from tumor cells is captured by DCs and binds with the cytosolic cGAS dimers, thereby activating their enzymatic activity to catalyze the reaction between adenylate triphosphate (ATP) and guanosine triphosphate (GTP) to generate 2′3′ cyclic GMP–AMP (cGAMP)15–17.