CASP3 and neoplasm: Western blot analysis on the tumor tissue samples further showed that BSA-Man@Mn2+-Ft@Lap significantly upregulated the expression levels of BAX and Caspase-3 in tumors while downregulating Bcl-2 expression (Fig. 6j), which was in good accordance with the apoptosis-inducing capability of Lap and effector T cells against tumor cells.