Similarly, we also observed that the immune cell activation and infiltration in B16F10-tumor-bearing C57 mice has been substantially enhanced after the treatment with BSA-Man@Mn2+-Ft@Lap, where the nanoagonist induced a significant increase in DC maturation (27%), M1/M2 macrophage ratio (0.52) and tumor-infiltrating CD4/CD8 T cell populations (9.72% and 21.48%). Here, CD4 is linked to neoplasm.