The trends of distal tumor growth in different groups indicated that the systemic immunity after Lap-mediated ICD or Mn2+-mediated cGAS-STING stimulation in DCs was insufficient to inhibit the progression of the poorly immunogenic distal tumors when acting separately, while the strategic coordination of the two modalities with BSA-Man@Mn2+-Ft@Lap could lead to almost complete remission of both the primary and distal tumors. Here, STING1 is linked to neoplasm.