Meanwhile, treating 4T1-luc tumor-bearing mice with BSA-Man@Mn2+-Ft@Lap induced a drastic increase in the amount of tumor-resident mature DCs (Fig. 7a) as well as the expression of p-STING, p-IRF3, and p-TBK1 therein, while the expression level of STING/IRF3/TBK1 remained unchanged similar to the in vitro observations (Fig. 6j). Here, IRF3 is linked to neoplasm.