Specifically, Ft@Lap would be selectively taken in by tumor cells via TfR1-mediated endocytosis to induce immunogenic apoptosis, thus releasing abundant tumor-derived dsDNA into the TME for the cGAS-mediated DNA sensing in DCs, while BSA-Man@Mn2+ is efficiently internalized by DCs via Man-mediated ligand-receptor binding and release Mn2+ ions after enzymatic lysosomal degradation to activate the cGAS-STING axis, eventually triggering the downstream immunostimulatory transcriptional activities. The gene discussed is CGAS; the disease is neoplasm.