HMGB1 and neoplasm: Previous studies already demonstrated that Lap could be activated by abundant endogenous NAD(P)H:quinone oxidoreductase 1 (NQO1) in tumor cells to induce tumor cell apoptosis and cause the release of immunostimulatory damage-associated molecular patterns (DAMPs) including high mobility group protein 1 (HMGB1), ATP, membrane calreticulin (CRT), heat shock protein 70 (HSP70) and dsDNA38–40.