TGFB1 and neoplasm: CAFs then support tumor growth through the promotion of angiogenesis via the secretion of a variety of growth factors such as VEGF, PDGF, EGF, FGF2, FGF5, GDF15 and the secretion of immunosuppressive cytokines including TGF-β, IL-6, CXCL12, CCL2, LIF, and GAS6 [33, 34].