CYP7A1 and metabolic disease: Multi-organoids model developed with microfluidic arrays were used to coculture stem cell-derived liver, intestine and stomach organoids; paracrine factors produced by intestinal organoids were detected to affect the expression of bile acid synthetase (CYP7A1) in liver organoids, which verified the interorgan interaction.226 Multiorgan metabolic diseases characterized by dynamic interactions between different organs, such as type 2 diabetes mellitus (T2DM), can be replicated through coculture interactions between different organoids.