The levels of HOXA5 transcripts ranked the lowest in breast cancer (15 studies), lung cancer (10 studies), colorectal cancer (6 studies), and melanoma (2 studies) and representative figures are shown in Fig. S3B–G, suggesting that HOXA5 may act as a tumor suppressor of cancer development, which is conserved in ECCA rather than ICCA. This evidence concerns the gene HOXA5 and colorectal cancer.