ERN1 and cancer: When we stratified the analysis for each cancer type, our results show that the rs196929 ERN1 variant is associated with skin cancer (OR = 2.07, 95% C.I. 1.27–3.37, p = 0.003) and breast cancer (OR = 1.83, 95% C.I. 1.13–2.99, p = 0.013) in the subset of patients that had tooth loss.