Weekly systemic administration of IFN-γ increased the infiltration of T lymphocytes in cold tumors,30 and intratumoral injection of IFN-γ increased the level of CXCL10 and CXCL11, cytokines promoting intratumoral immune cell infiltration, in melanoma patients.31,32 However, SACC patients have a higher level of plasma IFN-γ but scarce tumor-infiltrating lymphocytes (TIL). The gene discussed is IFNG; the disease is melanoma.