RNF187 and osteosarcoma: For example, Chen et al. demonstrated overexpression of RNF187 induced cell EMT and apoptosis resistance in NSCLC [49]; Shi et al. revealed high level of RNF187 contributed to progression and drug resistance of osteosarcoma [50]; Liu et al. identified an essential oncogenic role of RNF187 in metastasis of hepatocellular carcinoma [51].