Therefore, the present study aims to examine the interaction between BMI-GRS according to 3 SNPs such as MC4R (rs17782313), CAV-1 (rs3807992), and Cry-1 (rs2287161) with HBI on abdominal obesity and obesity-related metabolic risk factors in overweight and obese women to provide valuable insights for preventive interventions at the level of individual, family, and community lifestyles and ultimately targeted nutritional and medicinal treatments. Here, CAV1 is linked to obesity due to melanocortin 4 receptor deficiency.