Ianniello et al. [43] also revealed that downregulation of METTL3 and METTL14 overcame the resistance of chronic myeloid leukemia cells to the TKI imatinib mesylate (imatinib) through regulating ribosome levels and translation. This evidence concerns the gene METTL3 and chronic myelogenous leukemia, BCR-ABL1 positive.