Figure 6C shows that the expression of COL6A1/2/3 in patients with COAD was significantly negatively associated with the RNAss and DNAss (p < 0.05), while positively correlated with stromal scores, immune scores, and estimate scores, and similar results were observed in READ (Fig. 6D). This evidence concerns the gene COL6A1 and colon adenocarcinoma.