Moreover, others demonstrated that PGD2 levels increase significantly by as much as sixfold in the hippocampal and/or cerebral cortical tissue of male Sprague–Dawley rats after traumatic brain injury (Kunz et al, 2002) or brain ischemia (Liu et al, 2013a, 2013b; Shaik et al, 2014). The gene discussed is HPGDS; the disease is brain ischemia.