In the brain, DP2 activation accelerates damage, as corroborated by studies with rat hippocampal neuronal and organotypic cultures in paradigms of glutamate toxicity (Liang et al, 2005, 2007) or aluminum overload (Ma et al, 2016), and in a rat model of type 2 diabetes (Yang et al, 2021). Here, PTGDR2 is linked to type 2 diabetes mellitus.