There are multifaceted non-inflammatory, anti-inflammatory, and proinflammatory functions shown by IgA.4Increased periodontal disease activity is seen as one of the indicators in GCF by IgA.5Periodontitis and diabetes have been bidirectional and are assessed through the pathogenicity; increase in clinical attachment loss is associated with diabetes and pre-diabetics.6, 7This study was done to estimate and compare the IgA levels in GCF using ELISA among type II diabetics and non-diabetics patients with periodontitis. This evidence concerns the gene CD79A and periodontal disorder.