PNPLA3 and liver disorder: When stratifying subjects on the presence of advanced fibrosis at baseline (F0‐2 or < 15 kPa, n = 451; F3‐4 or ≥ 15 kPa, n = 79) a significant association between carriage of the PNPLA3 G/G genotype and a higher rate of development of severe liver disease was detected in the group without (aHR 2.49, 95% CI = 1.05–5.89) but not in the group with advanced fibrosis (aHR 0.89, 95% CI = 0.21–3.74) (Figure 2).