We found homozygous CLEC7A c.714T>G; p.Y238* in 3 of 67 patients with DCM (4.5%) compared with 680 of 141,265 (0.48%) in the reference Genome Aggregation Database [gnomAD, version 2.1 (18)] (P = 0.0027, Fisher’s exact test) (Supplemental Figure 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.159491DS1). Here, CLEC7A is linked to familial dilated cardiomyopathy.