In the DCM validation cohort, specific variants in both CLEC7A and PLCG2 were again overrepresented: CLEC7A I223S (P = 0.0444; OR, 3.44 [95% CI, 1.03–11.50]) and PLCG2 R268W (P = 0.0276; OR, 2.49 [95% CI, 1.11–5.59]). Here, PLCG2 is linked to familial dilated cardiomyopathy.