DUOXA1 and familial dilated cardiomyopathy: In total, STAT3 haploinsufficient mutations, variants in the DECTIN-1 fungal recognition pathway and H2O2-producing pathways involving DUOX1/DUOXA1 were found in 34 of 67 patients with DCM (50.7%) (Figure 3), spanning fungal recognition and response in both hematopoietic and nonhematopoietic compartments.