In this regard, the facial dysmorphisms, reduced head circumference, hydrocephalus, growth retardation, and neonatal failure to thrive of patients with Temple syndrome strongly overlap with the abnormalities of Dio3–/– mice, supporting a partial role for DIO3 deficiency and the associated developmental thyrotoxicosis. This evidence concerns the gene DIO3 and motor developmental delay due to 14q32.2 paternally expressed gene defect.