IL37 and alkaline phosphatase measurement: Here, we explored the crucial role and potential mechanism of IL-37 in AP and found that (a) clinical data demonstrated that serum IL-37 was negatively correlated with complications such as PN; (b) IL-37 protected against acinar cell death both in vivo and in in vitro experimental AP; and (c) IL-37 rescued experimental acinar cell death dependent on the pyroptosis pathway.