A genome-wide association study carried out in a large cohort identified glypican-1 (GPC1) and adducin 3 (ADD3) as susceptibility factors of BA [15], and further research confirmed that abnormal localizations of ADD3 and a GPC1-encoded protein exist in BA [16], but a more comprehensive, whole-genome mutation survey in a large cohort is required for further progress. Here, ADD3 is linked to breast angiosarcoma.