Despite limited specificity [51, 96], NAG is a promising prognostic biomarker for CRS and could also represent a potential therapeutic target since it decreases in response to diuretic-induced decongestion similar to BNP/NT-proBNP [51, 100], which is particularly interesting since venous congestion is the major pathophysiological driver of CRS [7•, 7, 51]. This evidence concerns the gene NPPB and congenital rubella syndrome.