KEGG pathway enrichment analysis identified the pathways of lysine degradation, transcriptional mis-regulation in cancers, B cell receptor signaling, cellular senescence, thyroid hormone signaling, Kaposi sarcoma-associated herpesvirus infection, ubiquitin-mediated proteolysis, endocytosis, RNA degradation, HTLV-l infection, ErbB signaling, viral myocarditis, human cytomegalovirus infection, neurotrophin signaling, natural killer cell-mediated cytotoxicity, and T cell receptor signaling as key pathways influenced by the differentially expressed circRNAs in SLE. The gene discussed is EGFR; the disease is cancer.