In view of the tumors, when the contralateral palpable BCs were excluded, the 64 screen-detected NPBC of the 32 BiNPBC patients were similar compared to the 55 screen-detected NPBC of 55 (N + AnyContra) PBC patients in terms of age at diagnosis, percentage of invasive BC, TNM stage, histological grade, multi-focality, ER, PR, Her2, Ki67 index, subtype, surgery, radiotherapy, Her2-targeted therapy, and endocrine therapy (Table 2). This evidence concerns the gene MKI67 and primary biliary cholangitis.