The current study aims at assessing the psychological profile of surgically or medically treated acromegaly patients, including the sleep quality, the cognitive and sexual functions, and the QoL, and at investigating whether these psychopathological dimensions are associated with age and gender and/or affected by specific illness traits, such as GH and IGF1 values, disease duration, and the co-occurrence of specific comorbidities associated with acromegalic disease. The gene discussed is GH1; the disease is acromegaly.