The results of the current study are in concordance with previous reports, demonstrating OSAS to occur in up to 78% of acromegaly patients (51, 52), with no significant impact of IGF1 levels, as expression of disease activity, on the prevalence and the severity of OSAS according to a recent meta-analysis, probably as a consequence of a partial and not complete resersibility of upper airways changes, induced by hormome excess, after hormone normalization (53). The gene discussed is IGF1; the disease is acromegaly.