In 2001, prior to the publication of the ESHRE guideline, Olive and Pritts3 proposed a medical therapy flowchart for pain in which they recommended NSAIDs or OCs/LEPs as the first line of treatment for endometriosis‐associated pain and GnRH agonists with add‐back therapy as an alternative choice when the first line of treatment is ineffective. This evidence concerns the gene GNRH1 and endometriosis.