One of these mechanisms is the abrogation of the mortalin-p53 complex that results in reactivation of p53 function and hence growth arrest/apoptosis/senescence in the cancer cells (Dundas et al., 2005; W. J. Lu et al., 2011b; Ma et al., 2006; Wadhwa et al., 1998). The gene discussed is TP53; the disease is cancer.