SMC2 and cancer: Furthermore, several natural metabolites such as, CAPE (from honeybee propolis), Fucoxanthin (from brown sea weeds), Wi-A and Wi-N (from Ashwagandha), Solasonine and Solamargine (from Solanum plants), Acantrifoside (Acanthopanax trifoliatus), Embelin (from Embelia ribes), Veratridine (from Veratrum and Liliaceous plants) have been shown to disrupt mortalin-p53 interaction and restore wild-type p53 activity in cancer cells (Abdullah et al., 2015; Hartati and Djauhari, 2020; Nigam et al., 2015; Pham et al., 2019).