Among these RASGs, the following have previously been reported to mediate the proliferation, migration, invasion, and apoptosis of cancer cells: Ribosomal protein S27a (RPS27A); LSM1 homolog, mRNA degradation associated (LSM1); legumain (LGMN); inverted formin 2 (INF2); LDL receptor related protein 5 (LRP5); and filamin A (FLNA) (Yu et al., 2021; Watson et al., 2008; Roslan et al., 2019; Zhang & Lin, 2021; Qian et al., 2018b; Qian et al., 2018a). Here, LRP5 is linked to cancer.