It is not only IRF7 that responds to viral infection, as this is also common to a group of interferon-stimulated genes (ISG), such as Orthomyxovirus resistance gene (Mx), oligoadenylate synthetase (OAS), ISG15, and Interferon-induced transmembrane protein 2 (IFITMs) (Garcia-Sastre, 2011). This evidence concerns the gene ISG15 and viral infectious disease.