The dynamic reversible process of histone methylation mediated by HMMRs was summarized in Figure 2A. We analyzed the gene expression profile of these 24 regulators in AML patients regarding their RiskStatus level, and results showed that there were 6 regulators endorsed with remarkable gene expression uniqueness in RiskStatus, including 1 writer (CARM1), 2 readers (ATRX and PC) and 3 erasers (KDM2A, KDM4A and KDM5B) (Figure 2B). Here, KDM4A is linked to acute myeloid leukemia.