NPM1 and acute myeloid leukemia: The somatic mutation analysis of AML-TCGA cohort displayed that the three most frequently mutated genes of the patients with low M-RiskScore were DNMT3A, KIT and WT1. In contrast, in the high M-RiskScore group, NPM1, DNMT3A and RUNX1 were observed the most frequently mutated genes (Figure 7D-E).