From the data in Figure 3, it can be seen that knockdown of lncRNA-PVT1 can downregulate the expression of MMP9, thereby promoting the apoptosis of LCC, and regulating the expression of MMP9 by knocking down lncRNA-PVT1 can increase the apoptosis rate of LCC by 16.2%. The gene discussed is MMP9; the disease is leukoencephalopathy with calcifications and cysts.