The results showed that the expression of MMP9 after knockdown of lncRNA-PVT1 was significantly reduced, and the proliferation of LCC was significantly reduced (P < 0.05), while the proliferation of LCC transfected with lncRNA-PVT1 was significantly higher than that of the observation group (P < 0.05). The gene discussed is MMP9; the disease is leukoencephalopathy with calcifications and cysts.