Although a recent GWAS revealed that APOE4 was associated with cognitive progression and ATP8B2 was associated with motor progression in longitudinal PD cohorts [7], a longitudinal genome-wide survival study revealed that RIMS2, TMEM108, WWOX, GBA, and APOE were involved in cognitive impairment progression in PD patients [10]. The gene discussed is APOE; the disease is Cognitive impairment.