Compared with the normal group, we found that the levels of immune factors (IgE, IgG1, and IgG2a), inflammatory factors (TNF-α, IFN-γ, and IL-4), and the expression and release levels of mRNA in Eotaxin were significantly upregulated in the serum of the AD and AD/substrate mice groups. Here, IL4 is linked to Alzheimer disease.