There were 13 genes enriched in cocaine addiction and the circadian entrainment signaling pathway (Bdnf, Gnai1, Gnai3, Grin2d, Grm2, Maob, Cam2, Camk2g, Gng12, Mapk1, Pcb4, Prkm2, and Pdyn). Here, BDNF is linked to cocaine dependence.