There were 13 genes enriched in cocaine addiction and the circadian entrainment signaling pathway (Bdnf, Gnai1, Gnai3, Grin2d, Grm2, Maob, Cam2, Camk2g, Gng12, Mapk1, Pcb4, Prkm2, and Pdyn). This evidence concerns the gene MAOB and cocaine dependence.