Enhancement of paracrine CXCR3 ligands (CXCL9, CXCL-10, and CXCL-11) in the tumor microenvironment and deactivation of CXCR3 expression on cancer cells could be antitumorigenic by recruiting activated natural killer cells and T lymphocytes with potent antitumor effects in various lung cancer models [124, 125]. Here, CXCR3 is linked to lung carcinoma.