Mice lacking the murine chloride channel accessory 3, mCLCA3, a murine ortholog of the human hCLCA1 implicated in inflammatory pulmonary disease, showed reduced neutrophilic infiltration after Staphylococcus aureus-induced pneumonia, which was accompanied by lower mRNA and protein levels of CXCL-1 (a murine CXCL-8 homolog), although there was no effect on mucus cell metaplasia or overall clinical outcome [149]. Here, CXCL1 is linked to pneumonia.