Blocking the CXCL8/CXCR1/2 axis with CXCL8 (3–72)G31P (pG31P), a CXCR1/2 antagonist, effectively mitigated LPS-induced pneumonia in mice by reducing the production of inflammatory cytokines such as CXCL8, TNF-α, and IL-1 and limiting neutrophil infiltration into the pulmonary parenchyma [153]. The gene discussed is CXCL8; the disease is pneumonia.