In this paper, 10 hub genes related to five diseases of COVID-19, IPF, CRC lung metastasis, SCLC, and NSCLC were identified by means of bioinformatics, namely NDC80, KIF4A, CKS1B, CEP55, PRIM1, TACC3, RRM1, SHCBP1, NUP37 and CCT5. This evidence concerns the gene RRM1 and non-small cell lung carcinoma.