In this paper, 10 hub genes related to five diseases of COVID-19, IPF, CRC lung metastasis, SCLC, and NSCLC were identified by means of bioinformatics, namely NDC80, KIF4A, CKS1B, CEP55, PRIM1, TACC3, RRM1, SHCBP1, NUP37 and CCT5. Here, RRM1 is linked to small cell lung carcinoma.