In this paper, 10 hub genes related to five diseases of COVID-19, IPF, CRC lung metastasis, SCLC, and NSCLC were identified by means of bioinformatics, namely NDC80, KIF4A, CKS1B, CEP55, PRIM1, TACC3, RRM1, SHCBP1, NUP37 and CCT5. The gene discussed is CKS1B; the disease is COVID-19.