Along with tumor volume changes, dox withdrawal in this tumor line also resulted in a significant decrease in Ki67 expression 2, 4, and 8 days after dox withdrawal (p < 0.05; Tukey test) and a significant increase in CC3 expression 4 and 8 days after dox withdrawal (p < 0.05; Tukey test) (Fig. 2b; n = 4 tumors, quantified in Supplementary Fig. 1b) like the fast-recurrence line. The gene discussed is MKI67; the disease is neoplasm.