This time point is termed “Primary.” After initial tumor growth reached 5 × 5 mm, dox was withdrawn from the drinking water, leading to Her2 downregulation and a reduction in tumor volume termed “Regression.” After the regression phase, a small population of residual cells survive for an extended period of time, termed “Dormancy,” prior to re-initiating proliferation, termed “Recurrence”39. Here, ERBB2 is linked to neoplasm.