We also found EGFR, MYCN, and MYC in brain cancers;39,40BCL2, MYC, and the loci of IGH translocations in lymph-nodes cancer;41–43CDK12 in breast cancer; CCND1 in liver cancer; and RUNX1, GATA6, and PDE4D in esophageal cancer (Fig. 5). The gene discussed is PDE4D; the disease is breast cancer.