We used the RNA-Seq data from the The Cancer Genome Atlas (TCGA) and Cancer Cell Line Encyclopedia (CCLE)14 databases, and found that cell adhesion-related pathway was predominantly enriched in both DNMT3A-mutatnt AML patients and cell lines (Fig. 1a), and inversely correlated with the survival of the patients (Fig. 1b). This evidence concerns the gene DNMT3A and cancer.