DNMT3A and acute lymphoblastic leukemia: To compare their biological effects on leukemogenesis, we tested the cytotoxicity of GDYO and GO in multiple leukemia cell lines and found that GDYO potently suppressed the proliferation of DNMT3A-mutant AML cell lines, while its effect on DNMT3A-wt AML cell lines (HL-60 and THP-1) and acute lymphoid leukemia cell lines (Jurkat and Nalm6) was more modest (Fig. 2d and Supplementary Fig. 6).