DNMT3A and acute myeloid leukemia: Furthermore, we analyzed RNA-seq datasets of the mouse LSK (Lin-Sca1+c-Kit+) cells isolated from mice with conditional knock-in of Dnmt3aR878H mutation15, as a model of DNMT3A-mutant AML featuring a common R878H mutation, and mouse HSCs sorted from Dnmt3a-/- mice5, as a model of complete loss of DNMT3A.