DNMT3A and acute myeloid leukemia: We noted that ITGB2, the first phagocytic integrin to be characterized32, and MRC2, a collagen receptor that serves to direct large collagen fragments to lysosomal degradation through phagocytosis33, exhibited the highest expression levels and were located on cell surface in DNMT3A-mutant AML cell lines (Fig. 4c, d).