We also analyzed the bisulfite sequencing data from AML TCGA database and found that promoter regions of both ITGB2 and MRC2 were hypomethylated (Supplementary Fig. 19a), which was associated with their high expression levels in DNMT3A mutant cells (Supplementary Fig. 19b). This evidence concerns the gene ITGB2 and acute myeloid leukemia.