This is also supported by the scRNAseq results, as IPF-ABCs overexpress known stemness genes such as transcription factors and inducers of pluripotency KLF4 and MYC, as well as AP1 forming c-JUN and FOSL1, which are downstream transcription factors of genes inducing pluripotency19 and important oncogenes for cancer stem cells20. Here, KLF4 is linked to cancer.