MCL1 and mood disorder: Given that dysregulation of either anti- or proapoptotic BCL-2 members is observed in mood disorders and that the hemostasis model among the BCL-2 members operates quite well in explaining their effect on cell survival [49, 50], it is possible that mood disorders associated with proapoptotic BLM-s deficit results from unbalanced over-activity of other antiapoptotic molecules such as BCL-2 or MCL-1.