FCGR3A and COVID-19: For this reason the formation of sICs could be an accelerating event in the causal chain of COVID-19 immunopathogenesis, e.g. by linking prevalent autoantibody formation in prone individuals with systemic activation of various FcγRIIIA/CD16A-bearing immune cells contributing to subsequent disseminated tissue destruction and multi-organ disease as observed in severely ill COVID-19 patients (see below).