Finally, we tested pooled patient sera for autoantibodies against a panel of prototypical autoantigens associated with autoimmune disease including anti-nuclear autoantibodies (ANA) by indirect immunofluorescence, dsDNA autoantibodies by ELISA and autoantibodies against the extractable nuclear antigens (nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, PM-Scl, Jo-1, CENP B, PCNA, nucleosomes, histones, ribosomal P-protein, AMA-M2, DFS70) by dot blot in case SARS-CoV-2 infection triggers autoantibody formation and possible sIC formation. Here, TRIM21 is linked to autoimmune disease.