Besides, the interaction between BMM and AML cell can also lead to the activation of phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT), wingless-related integration site (Wnt), NOTCH, and other signal pathways, which play key roles in the regulation of AML cells’ maintenance, proliferation, and differentiation (Fig. 2). Here, AKT1 is linked to acute myeloid leukemia.