Recently, an in vivo and in vitro study by Habbel et al. confirmed that AML cells could secrete inflammatory cytokines and activate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways in both AML blasts and BMSCs, thereby increasing the ROS generation and AML proliferation. Here, SOAT1 is linked to acute myeloid leukemia.