However, in addition to multiple studies supporting the detrimental role of the LIGHT pathway in several inflammatory diseases as described above, the protective effect of this molecule in inflammatory bowel disease and beige fat biogenesis by inhibiting inflammatory cytokine expression [31, 33, 34, 41, 42] and in cisplatin-induced AKI by ameliorating mitochondrial apoptosis have been reported [36]. This evidence concerns the gene TNFSF14 and inflammatory bowel disease.