Two CTLA4 genetic variants have been linked with the development of vitiligo, i.e., +49A/G (rs231775), an exon 1 missense variation leading to a threonine to alanine substitution at codon 17 (T17A); and CT60 A/G (rs3087243), located 236 bp downstream of the CTLA4 3′-UTR.10 This evidence concerns the gene CTLA4 and vitiligo.